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抑制性CARs无法防止T细胞的直接细胞毒性

Maximilian A Funk1, Gerwin Heller2, Petra Waidhofer-Söllner3

  • 1Center for Pathophysiology, Infectiology and Immunology, Institute of Immunology, Division for Immune Receptors and T Cell Activation, Medical University of Vienna, Vienna, Austria; University Hospital LMU Munich, Department of Medicine III, Munich, Germany; Gene Center, LMU Munich, Cancer and Immunometabolism Research Group, Munich, Germany; German Cancer Consortium (DKTK), Munich Site and German Cancer Research Center, Heidelberg, Germany.

Molecular therapy : the journal of the American Society of Gene Therapy
|February 22, 2024
PubMed
概括

抑制性化学抗原受体 (iCARs) 旨在提高CAR-T细胞治疗的特异性. 然而,iCARs并没有阻止T细胞杀死表达抗原的健康细胞,这表明潜在的功能障碍.

关键词:
布尔式关是布尔式关的一个方法.在CAR-T细胞中.抑制性CAR是一种抑制性CAR.逻辑门的逻辑门.结合性的抗原向向.这就是iCAR的意义.在瘤上,在瘤之外的毒性.

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