泌尿器官微生物驱动的毒性因子基因与反复复发的尿路感染相关
Lei Jiang1, Haiyun Wang1, Lei Luo1
1Department of Urology, Affiliated Hospital of Qingdao University, Qingdao, China.
Frontiers in microbiology
|February 22, 2024
概括
房间里的人.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 遗传学 是一个遗传学.
背景情况:
- 经常性尿路感染 (rUTI) 是一个严重的临床问题,其机制尚不清楚.
- 尿路微生物组 (urobiome) 越来越多地与尿路感染的发展和复发有关.
- 在rUTI中由dodaome驱动的特定毒性因子基因 (VFGs) 没有得到很好的特征.
研究的目的:
- 为了研究多巴基因驱动的VFGs和复发性尿路感染之间的关系.
- 为了确定与RUTI相关的特定VFG特征.
- 开发使用VFG水平的RUTI诊断模型.
主要方法:
- 在RUTI患者和健康对照的尿路微生物组中对VFG成分的比较分析.
- 机器学习模型 (随机森林,支持矢量机) 用于诊断模型开发.
- 接收器操作特征 (ROC) 曲线分析以评估诊断准确性.
主要成果:
- 与对照人群相比,RUTI患者的尿路微生物组中观察到更高的α多样性.
- 在患有复发性感染的患者中发现的特定VFG的丰度增加.
- 开发了一种具有AUC值为0.83和0.75的诊断模型,用于区分尿路感染状态.
结论:
- 基因组驱动的VFGs在复发性尿路感染中起着重要作用.
- 特定的VFG可以作为诊断和监测RUTI的生物标志物.
- 研究结果突出了预防尿路感染复发的潜在治疗目标.
相关概念视频
Genomic DNA in Prokaryotes
43.9K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic Diversity in Bacteria
Although bacterial genomes are much...
43.9K
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
Surface Membrane Barriers
1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K
Disorders of the Urinary System
300
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
300
Genome Size and the Evolution of New Genes
8.0K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
8.0K
Sexually Transmitted Infections
308
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
308


