移植前的甲状腺功能障碍和移植或移植后的患者结果
Fernanda Guedes Rodrigues1,2, Willemijn Y Van Der Plas3,4, Camilo German Sotomayor1
1Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
概括
在移植之前的严重甲状腺功能过高并不会影响移植功能或存活率. 这项研究发现,在患有高副甲状腺激素水平的患者中,移植功能延迟,移植失败或死亡的风险没有增加.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
- 内分泌学 在内分泌学.
背景情况:
- 移植前甲状腺激素 (PTH) 水平对脏移植结果的影响受到辩论.
- 在移植候选人中,严重的副甲状腺功能障碍是常见的.
研究的目的:
- 评估移植前PTH水平与脏移植结果之间的关联.
- 调查严重的甲状腺功能过高和延迟移植功能 (DGF),死亡审查的移植失败 (DCGF) 和全因死亡率之间的联系.
主要方法:
- 在1576名脏移植接受者的单中心队列研究中.
- 使用多变量后勤和考克斯回归分析来评估PTH和骨/矿物代谢参数.
- 严重的副甲状腺炎症定义为移植前PTH≥771 pg/mL.
主要成果:
- 在121名患者中存在严重的偏甲状腺症 (PTH ≥771 pg/mL).
- 在更高的移植前PTH和DGF (HR 1.06),DCGF (HR 0.98) 或全因死亡率 (HR 1.02) 之间没有发现显著的关联.
- 研究结果在敏感性分析和其他骨/矿物代谢参数 (如性酸酶 (ALP)) 中一致.
结论:
- 严重的移植前副甲状腺功能障碍与不良脏移植结果无关.
- 在移植之前纠正严重的副甲状腺功能障碍并未得到支持,以改善移植或患者的生存率.
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