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在COVID-19感染后发生自身免疫性甲状腺疾病的发展:病例报告
Si-Na Du1, Jian-Wei Chen1, Wei Li2
1Department of Endocrinology, Cixi People Hospital Medical Health Group (Cixi People Hospital), Cixi, China.
Frontiers in medicine
|February 22, 2024
概括
COVID-19 感染可以在患者中引发各种自身免疫性甲状腺疾病反应. SARS-CoV-2 免疫刺激改变了诸如 Hashimoto 甲状腺炎和 Graves 病等疾病的发展过程,突出显示了病毒感染和甲状腺自身免疫之间的联系.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 严重急性呼吸系统综合征-冠状病毒-2 (SARS-CoV-2) 可以引起多方面的免疫反应.
- 这些免疫反应越来越多地与自身免疫疾病的发展或恶化有关,包括各种甲状腺疾病.
- 了解SARS-CoV-2对甲状腺自身免疫力的影响对于患者管理至关重要.
研究的目的:
- 描述COVID-19感染后患者自身免疫性甲状腺疾病的临床过程和疾病进展.
- 分析SARS-CoV-2感染对先前存在的和新出现的自身免疫性甲状腺疾病的影响.
主要方法:
- 一系列病例报告了五名患者的临床特征,诊断和治疗.
- 在COVID-19感染后一个月,甲状腺疾病演变的详细检查.
主要成果:
- 一名患有哈西莫托甲状腺炎的患者患有格雷夫斯病;另一个患有哈西莫托和结节的患者也患有格雷夫斯病,两者都显示出增强的甲状腺刺激抗体.
- 一名患有稳定的格雷夫斯病的患者出现了恶化的症状,甲状腺刺激抗体升高.
- 一位先前患有甲状腺功能低下症的患者显示甲状腺相关抗体活性增加 (TPOAb,TRAb) 和甲状腺功能低下症恶化.
- 一个没有甲状腺病史的患者在感染后出现了无痛的甲状腺炎和甲状腺毒素症.
结论:
- 在患有自身免疫性甲状腺疾病的患者中,COVID-19感染可能会导致不同的临床结果.
- 观察到的甲状腺疾病趋势的变化与SARS-CoV-2引起的免疫反应密切相关.
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