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Updated: Jul 2, 2025

Protein Purification-free Method of Binding Affinity Determination by Microscale Thermophoresis
10:22

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Published on: August 15, 2013

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针对细胞选择性和向性降解激活的STAT3的Oligo-PROTAC战略

Jeremy Hall1, Zhuoran Zhang1, Supriyo Bhattacharya2

  • 1Department of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.

Molecular therapy. Nucleic acids
|February 22, 2024
PubMed
概括

这项研究开发了一种新型的蛋白质分解向化母 (PROTAC) 策略,以向癌症中的关键蛋白质STAT3. 这种新化合物C-STAT3DPROTAC有效地降低了淋巴瘤细胞中的STAT3水平,并导致小鼠的瘤回归.

关键词:
MT:寡核酸:治疗方法和应用.这就是PROTAC.在STAT3中,我们可以使用STAT3.在TLR9中,这就是为什么Cereblon.诱 诱 是一个诱.淋巴瘤淋巴瘤是什么这是一种寡核化物.蛋白质溶解过程中的蛋白质溶解.

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