在肥胖的Wistar大鼠中,不同食用油对肝酶的低脂效应和调节
Md Abdul Alim1, Tarana Jannat Mumu1,2, Ummay Salma Tamanna1,3
1Department of Food Technology and Nutritional Science, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Tangail, 1902, Bangladesh.
Heliyon
|February 22, 2024
概括
米,鱼肝和向日油等食用油可以帮助控制肥胖,改善大鼠的脂质概况. 这些油有效地降低了体重,肝脏脂肪,调节了肝脏关键酶和胆固醇水平.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肥胖是一个日益严重的健康问题,与失脂血症和肝脏酶活性改变有关.
- 食用油是饮食的主食,它们对代谢健康的影响需要调查.
研究的目的:
- 为了评估各种食用油的低脂效应.
- 评估肥胖大鼠中不同食用油对肝酶的调节.
主要方法:
- 36只Wistar大鼠被分为高脂肪饮食 (HFD) 和对照组.
- 肥胖的老鼠随后用不同的食用油 (大米油,橄油,大豆油,鱼肝油,向日油) 或持续HFD治疗5周.
- 分析了体重,器官重量,肝脂肪,血清肝酶 (AAT,EAT,ALT,GGT) 和脂质样本 (TC,TAG,LDL-C,HDL-C) 的情况.
主要成果:
- 与持续高脂肪 (CHF) 组相比,大米油 (RBO),鱼肝油 (CLO) 和向日油 (SFO) 的体重减少不显著.
- RBO,橄油 (OO),大豆油 (SO),CLO和SFO显著减少了腹内脂肪组织 (IBAT) 和肝脂肪.
- RBO,OO,SO和CLO显著降低了氨酸转移酶 (ALT) 水平,而RBO也显著降低了马-氨基转移酶 (GGT).
- 所有测试的油都有效地降低了总胆固醇 (TC),甘油三 (TAG) 和LDL胆固醇 (LDL-C),同时增加了HDL胆固醇 (HDL-C).
结论:
- 食用油具有改善肥胖症和改善肥胖个体脂质概况的潜力.
- 特定的食用油显示肝酶的显著调节,有助于它们的低脂效应.
- 用精选的食用油进行饮食干预,为管理与肥胖相关的代谢障碍提供了一个有希望的策略.
相关概念视频
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
661
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
661
01:29Cholesterol: Significance and Regulation
544
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
544
01:24Overview of Lipid Metabolism
1.6K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.6K
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
163
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
163
01:18Lipids: Dietary Sources and Requirements
739
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
739