慢性HBV的波尔托-鼻状血管疾病:一个重要的共存不能被忽视
Pol Olivas1,2, Valeria Perez-Campuzano1,2, Lara Orts1,2
1Liver Unit, Hospital Clínic, Fundació Recerca Clínic Barcelona- Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). Departament de Medicina i Ciències de la Salut. Universitat de Barcelona. Centro de Investigación biomédica Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
慢性乙型肝炎 (CHB) 在波多鼻状血管疾病 (PSVD) 患者中更为普遍,导致诊断延迟和结果更差. 早期识别这种共存对于改善PSVD患者管理至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 血管性肝脏疾病 血管性肝脏疾病
- 病毒性肝炎病毒性肝炎
背景情况:
- 波多鼻状血管疾病 (PSVD) 的特点是血管异常导致门口高血压而没有肝硬化.
- 目前的诊断标准允许与其他肝脏疾病同时发生,但与慢性乙型肝炎 (CHB) 的关系尚不清楚.
研究的目的:
- 确定PSVD患者中乙型肝炎病毒 (HBV) 感染的流行率.
- 评估同时存在的CHB对PSVD诊断和结果的临床影响.
主要方法:
- 在巴塞罗那Clínic医院对155名PSVD患者的回顾性分析.
- 评估HBV血清学以将患者分类为慢性感染,过去感染或没有HBV暴露.
- 具有和没有CHB的PSVD患者之间的临床特征和结果的比较.
主要成果:
- 在PSVD患者中,CHB (5.8%) 和过去的HBV感染 (20%) 的患病率明显高于一般人群.
- 患有CHB的患者在PSVD诊断中经历了显著的延迟 (11年对1年),并呈现出更先进的疾病 (MELD得分12对9).
- 患有CHB的PSVD患者的肝移植率大大提高 (33%对4.1%).
结论:
- PSVD和CHB的共存比以前认为的更为常见.
- CHB显著影响PSVD诊断和临床过程,导致结果较差.
- 及时诊断和管理策略对于患有CHB的PSVD患者至关重要.
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