费里丁纳米聚合诱导的排放纳米聚合物用于NIR-II光导向的非侵入性,可控制的男性避孕药
Xinghua Yu1, Jiaxue Shuai1, Ge Meng1
1Department of Urology & Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, China.
Materials today. Bio
|February 22, 2024
概括
人类重链费里 (HFn) 纳米载体与AIEgens提供非侵入性男性避孕. 近红外光激活HFn@BBT用于可控制的高温症,可逆或永久影响生育能力.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 生殖生物学 生殖生物学
背景情况:
- 以前使用金纳米棒的男性避孕方法面临丸管理和非生物降解性的挑战.
- 存在对非侵入性,可控制和可生物降解的男性避孕策略的需求.
研究的目的:
- 开发一种非侵入性,可控制的男性避孕方法,使用载有聚合诱导排放光原体 (AIEgens) 的人类重链费里 (HFn) 纳米载体.
- 为了指导该过程,使用近红外II (NIR-II) 光成像.
主要方法:
- 人类重链费里 (HFn) 纳米载体封装AIEgens (HFn@BBT) 被合成.
- HFn@BBT是静脉注射的,并通过近红外辐射激活,以诱导丸高温症.
- 在较低和较高的高温治疗后,评估了生育指数和丸损伤.
主要成果:
- 下部高温症在第7天使生育能力降低了大约100%,到第60天逐渐恢复到80%.
- 升高的热量导致60日完全丧失生育能力,原因是丸完全被破坏.
- 通过AIEgens,可以进行增强的NIR-II光成像,并提高透深度.
结论:
- 基于HFn的纳米载体为非侵入性和可控制的男性避孕提供了一个有前途的平台.
- 治疗性高温和诊断性NIR-II成像的双重功能为生殖健康技术提供了重大进展.
- 这种方法解决了以前方法的局限性,为更安全的男性避孕方案铺平了道路.
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