在CTSA试点研究中区分翻译科学和翻译研究:一个跨越12个CTSA中心的合作项目
Margaret Schneider1, Amanda Woodworth1, Marissa Ericson1
1The Institute for Clinical and Translational Science, University of California, Irvine, CA, USA.
Journal of clinical and translational science
|February 22, 2024
概括
国家卫生研究院 (NIH) 临床和翻译科学奖 (CTSAs) 资助的试点研究正在将重点转移到翻译科学 (TS). 使用TS原则的新方法有效地将TS与翻译研究 (TR) 区分开来.
科学领域:
- 翻译科学是翻译的科学.
- 医疗服务研究 医疗服务研究
- 生物医学研究的研究.
背景情况:
- 国家卫生研究院 (NIH) 临床和翻译科学奖 (CTSAs) 网络旨在将科学观察转化为公共卫生干预措施.
- 在CTSA中,越来越多地强调翻译科学 (TS) 而不是翻译研究 (TR).
- 新的NIH资金公告要求试点研究重点关注翻译过程的科学原则,需要明确区分TR和TS.
研究的目的:
- 评估一套由国家翻译科学发展中心 (NCATS) 开发的翻译科学原则 (TSPs) 的实用性.
- 确定TSP是否能够有效地区分翻译研究 (TR) 和翻译科学 (TS) 试点项目.
主要方法:
- 十二个CTSA中心合作创建了一个TSP问题列表.
- 二十九个试点计划管理员使用这些TSP问题评估了26个CTSA资助的试点研究.
- 用因子分析来确定TSP问题中的基本结构.
主要成果:
- 因子分析确定了三个关键因素:通用性/效率,颠覆性创新和团队科学.
- 概括性/效率因子解释了TS和TR项目之间的最大差异和显著区别,由专家小组验证.
- 这个因素包括七个问题,可以帮助评估与NCATS对TS的愿景的一致性.
结论:
- 来自TSP的通用性/效率因子在区分翻译科学和翻译研究方面表现有前途.
- 这个因素中的七个问题可以帮助管理员评估试点研究是否符合TS目标.
- 该框架支持CTSA计划的战略方向,以推进翻译科学原则.
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