在临床研究中采用贝叶斯分析的实用指南
Lauren B Gunn-Sandell1,2, Edward J Bedrick3, Jacob L Hutchins4
1Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA.
Journal of clinical and translational science
|February 22, 2024
概括
贝叶斯分析现在可以用于临床和翻译 (C&T) 研究. 这项研究证明了其在临床试验中的应用,为C&T研究人员提供了可靠实施贝叶斯方法的指导.
科学领域:
- 生物统计学 生物统计学
- 临床研究方法论 临床研究方法论
背景情况:
- 贝叶斯统计方法在临床和翻译 (C&T) 研究中未得到充分利用,尽管它们在统计方法学中很普遍.
- 需要加强C&T研究人员对解释和实施贝叶斯分析的信心.
研究的目的:
- 加速在C&T研究中采用新的贝叶斯统计方法.
- 为在C&T环境中应用贝叶斯分析提供实际指导和示例.
主要方法:
- 开发和实施贝叶斯数据分析计划,用于双臂临床试验.
- 对比了一种新的阿片类药物在术后疼痛管理中的有效性.
- 证明了四个贝叶斯统计包 (STATA,SAS,RStan) 的应用,用于线性回归和后勤回归.
主要成果:
- 贝叶斯分析结果在不同的统计数据包和先前分布中是稳定的.
- 对于线性回归来说,STATA是用户友好的,但在模型拟合和总结方面存在局限性.
- SAS和R为后期分析提供了更好的文档和数据管理,并为复杂的模型提供了更大的灵活性.
结论:
- 贝叶斯分析现在可以让更广泛的数据分析师使用.
- 贝叶斯方法应在复杂问题的C&T研究中得到更广泛的考虑.
- C&T研究团队可以从采用和解释贝叶斯的方法来进行高级分析中获益.
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