血金属元素与中国老年人认知障碍风险之间的关联
Xin Wang1, Binbin Wang2, Fuwen Yang1
1Department of Neurology, Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Taiyuan, China.
Frontiers in aging neuroscience
|February 22, 2024
概括
较低的血,和铁,以及较高的,与中国老年人的认知障碍风险有关. 这些发现可能会为推迟认知衰退的策略提供信息.
科学领域:
- 老年学是指老年学的学科.
- 营养神经科学 营养神经科学
- 生物化学 生物化学
背景情况:
- 血金属元素与认知功能之间的关系仍然不清楚,特别是在非常老的.
- 认知障碍 (CI) 对全球老年人群构成了重大健康挑战.
研究的目的:
- 研究血金属度与90岁及以上中国成年人认知障碍 (CI) 风险之间的关联.
主要方法:
- 在408名90岁以上的参与者中分析了 (Se), (Mn), (Mg), (Ca),铁 (Fe),铜 (Cu) 和 (Zn) 的血度.
- 认知功能的评估是使用中文版的迷你精神状态考试进行的.
- 诱导合等离子光学发射光谱学用于金属元素测量.
主要成果:
- 与认知正常个体相比,CI患者的血Se,Mn和Fe水平显著降低,Ca水平更高 (p < 0.05).
- 在逻辑回归模型中,血Se,Mn,Ca和Fe度与CI风险有显著的关联.
- Se,Mn和Fe的最高四分位数与CI风险降低有关,而Ca的最高四分位数与CI风险增加有关 (提供调整后的OR).
结论:
- 血Se,Mn和Fe的降低和血Ca水平的增加与中国老年人认知障碍的风险增加有关.
- 这些发现突出了特定金属元素在非常老年人认知健康中的潜在作用.
- 这些结果对开发旨在延迟老年人群认知衰退的干预措施有影响.
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