在患有慢性病的成年人中,交感活动和脉冲波速度的性别差异
Matias G Zanuzzi1,2, Jinhee Jeong1,2, Dana R DaCosta1,2
1Division of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
American journal of physiology. Renal physiology
|February 22, 2024
概括
患有慢性病 (CKD) 的男性比女性表现出更高的交感神经系统 (SNS) 活动. 然而,血管硬性在两性之间没有差异,这表明非神经因素会影响CKD中的硬性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心血管生理学心血管生理学
- 自主神经科学 自主神经科学
背景情况:
- 慢性病 (CKD) 与交感神经系统 (SNS) 的过度活动有关,有助于血管硬和心血管风险.
- 现有研究强调了CKD中SNS活动升高和血管硬,但性别特异性差异在很大程度上仍未被探索.
研究的目的:
- 研究CKD患者自主和血管功能的潜在性别差异.
- 为了测试这一假设,与女性相比,患有CKD的男性具有更高的基线交感活动和动脉硬性.
主要方法:
- 招募了129名参与者 (96名男性,33名女性) 患有CKDIII-IV阶段.
- 评估血管硬度使用心血管至大腿脉冲波速率 (cfPWV).
- 通过微神经图测量休息肌肉交感神经活动 (MSNA).
主要成果:
- 患有CKD的男性的休息MSNA显著高于女性 (68±16比55±14爆发/100心跳,P=0.005).
- 在CKD的男性和女性之间没有观察到cfPWV的显著差异 (P=0.248).
- 休息的MSNA与两性中cfPWV没有相关性.
结论:
- 与女性相比,患有CKD的男性在休息时表现出更大的同情活动.
- 血管硬性在CKD中没有性别差异.
- 由于MSNA和cfPWV之间缺乏相关性,这表明非神经机制对于CKD血管硬性进展至关重要,特别是在女性中.
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