治疗阿片类药物诱导的吞失调和呼吸系统抑郁的血清激素疗法
Michael Frazure1, In Morimoto2, Nathan Fielder3
1Department of Physiology, School of Medicine, University of Louisville, Louisville, Kentucky, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|February 22, 2024
概括
阿片类药物布普伦诺芬抑制吞和呼吸,女性更容易受到影响. 5-HT1A激动剂显示出逆转这些阿片类药物诱导作用的潜力,为治疗呼吸系统抑郁和消化不良提供了希望.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 众所周知,阿片类药物会导致呼吸抑制.
- 临床证据表明,阿片类药物可能会导致食欲障碍,但它们对吞刺激性和运动模式的影响尚不清楚.
- 越来越多地认识到阿片类药物影响的性别特异性差异.
研究的目的:
- 调查阿片类药物布普伦诺芬对雄性和雌性大鼠喉吞和呼吸驱动的作用.
- 评估5-HT1A激动剂 (8-OH-DPAT和巴斯皮龙) 对抗布普伦诺芬诱导的呼吸和吞缺陷的潜力.
- 探索性别特异性对阿片类药物诱导的呼吸和吞抑郁症的脆弱性.
主要方法:
- 吞和呼吸肌肉的电肌图 (EMG) 活动 (肌,甲状腺,后,甲状腺,腹膜) 在麻醉的斯普拉格-道利大鼠中记录下来.
- 吞是通过食道张张和口服水输液引起的.
- 分析了布普伦诺芬和5-HT1A激动剂 (8-OH-DPAT,巴斯皮龙) 对EMG活性和呼吸驱动的影响.
主要成果:
- 与吞相关的EMG活性在由食道张张和口服水输液联合引起时得到增强.
- 布普伦诺芬显著抑制了两性人的吞,女性更容易出现完全的吞抑制.
- 与男性相比,女性对阿片类药物诱导的呼吸抑制的脆弱性增加.
- 5-HT1A激动剂8-OH-DPAT在布普伦诺芬引起的呼吸暂停后挽救了呼吸,并在吞时增强了EMG活性.
- 在暴露于布普伦诺芬的雌性大鼠中,布斯皮龙预治疗预防了呼吸停止.
结论:
- 布普伦诺芬对吞和呼吸驱动有性别特异性的影响,女性更容易受到影响.
- 5-HT1A激动剂在减轻阿片类药物诱导的呼吸抑制和呼吸障碍方面显示出潜在的治疗效用.
- 这项研究提供了临床前证据,支持使用5-HT1A激动剂来控制阿片类药物对呼吸和吞的不良影响.
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