食消费,遗传风险和发生的肥胖:一项前性研究
Xuzhi Wan1, Yang Ao2, Xiaohui Liu2
1Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, Zhejiang, China. y_zhang@zju.edu.cn.
Food & function
|February 22, 2024
概括
大量食用油炸食品会增加肥胖的风险,尤其是腹部肥胖. 这种风险对具有较低遗传倾向的人来说更大,这表明个性化的饮食建议.
科学领域:
- 营养科学 营养科学
- 遗传学 遗传学 是一个
- 肥胖问题研究研究
背景情况:
- 遗传和饮食因素影响肥胖.
- 根据遗传学来个性化饮食建议,用于肥胖管理的证据有限.
- 食消费是一种常见的饮食习惯,与肥胖有潜在的联系.
研究的目的:
- 调查炸食品消费与整体和腹部肥胖的发生率之间的联系.
- 为了确定遗传倾向是否会改变油炸食品摄入量和肥胖风险之间的关系.
- 为预防肥胖提供个性化的饮食建议.
主要方法:
- 利用了来自27,427名英国生物库参与者的数据,提供了饮食和人类识别信息.
- 根据940个与身体质量指数 (BMI) 相关的变体计算了基因风险评分 (GRS).
- 采用生存分析来评估炸食品摄入量,GRS和肥胖发病率之间的关联,平均随访时间为8.1年.
主要成果:
- 较高的炸食品消费与整体肥胖 (HR=1.31) 和腹部肥胖 (HR=1.27) 的风险增加有关.
- 对腹部肥胖风险 (P=0.016) 的油炸食品摄入量和肥胖GRS之间观察到显著的相互作用 (P=0.016).
- 具有较低遗传风险的个体在增加油炸食物摄入时,腹部肥胖的风险显著增加 (HR=1.59).
结论:
- 对于具有较低遗传倾向的人来说,炸食品的消费构成更高的腹部肥胖风险.
- 对于那些基因风险较低的人来说,炸食品限制的饮食建议可能特别有益.
- 研究结果支持遗传个性化饮食策略在肥胖管理中的潜力.
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