化哈夫和共同支持核心-多异质纳米晶体的可调节生物降解性,用于生物成像
Qiang Wang1, Hang Shangguan1, Hongtao Yu1
1Key Laboratory of Forest Plant Ecology, Ministry of Education, College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, P. R. China.
Nano letters
|February 22, 2024
概括
研究人员开发了用于先进生物成像的新型,可生物降解的化纳米晶体 (LDNCs). 这些HZC纳米晶体提供可调节的降解,并使多模式成像成为可能,改善临床翻译潜力.
科学领域:
- 纳米技术纳米技术
- 生物医学成像技术 生物医学成像技术
- 材料科学 材料科学 材料科学
背景情况:
- 由于近红外 (NIR) 激发,兰化物合纳米晶体 (LDNC) 在生物成像中很受欢迎.
- 传统的LDNC具有刚性网格,限制了它们的体内降解和临床使用.
- 生物降解性对于纳米材料的安全有效的in vivo应用至关重要.
研究的目的:
- 开发一种新的,可生物降解的LDNC,可调节降解,用于增强的多模生物成像.
- 为了提高LDNCs的发光性能和体内性能.
- 通过多式成像来实现瘤特异性诊断.
主要方法:
- 合成了一个异质的核心--LDNC:Na3HfF7:Yb,Er@Na3ZrF7:Yb,Er@CaF2:Yb,Zr (HZC).
- 用氧化藻酸盐 (OSA) 改性HZC增强生物相容性,并使瘤向.
- 通过"软"格子结构和不同的Zr4+兴奋剂来研究可调的可降解性.
- 评估了上转换 (UC) 和下转换 (DC) 排放,以及计算机断层扫描 (CT) 的对比效应.
主要成果:
- 通过结构设计,在HZC纳米晶体中实现了可调节的生物降解性.
- 与核心纳米晶相比,显著提高了UC红色 (31.23倍),UC绿色 (150.60倍) 和DC NIR-II (19.42倍) 的排放.
- 证明了HZC在三模成像 (NIR-II/CT/UC) 和瘤特异性诊断方面的能力.
- 通过对OSA进行修改,确保了极好的生物相容性.
结论:
- 开发的HZC纳米晶体提供可调节的生物降解性和增强的多式联络成像能力.
- 在先进的生物成像和瘤特异性诊断方面,HZC显示出前途,克服了传统LDNCs的局限性.
- 这些发现为医学成像中可生物降解的LDNCs的临床转化铺平了道路.
相关概念视频
01:18Imaging Biological Samples with Optical Microscopy
Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
01:26Phase Contrast and Differential Interference Contrast Microscopy
Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...