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新型水 schiff 的基衍生物聚氨:合成,在体外的prolyl oligopeptidase 抑制活性及其分子对接研究

Faiz Talab1, Aftab Alam1, Zainab2

  • 1Department of Chemistry, University of Malakand, Khyber Pakhtunkhwa, Pakistan.

Journal of biomolecular structure & dynamics
|February 22, 2024
PubMed
概括

研究人员合成了新型的海德希夫基与多基诺林核,显示出显著的prolyl oligopeptidase抑制活性. 化合物3,15和14表现出优异的抑制,分子建模证实了潜在药物开发的稳定相互作用.

关键词:
核磁共振光谱法 (NMR) 是一种光谱法.化 船舶基础 船舶基础分子对接和分子动力学聚氨酸氨酸的使用方法普罗利尔寡酸酶的使用.结构-活动关系关系.

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Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...