在实体器官移植接受者中对候群病的评估
Nuran Sari1, Tuğba Yanik Yalçin, Çiğdem Erol
1From the Department of Infectious Disease and Clinical Microbiology, Baskent University Faculty of Medicine, Ankara, Turkey.
概括
固体器官移植接受者面临着高风险的候选血症,严重的真菌感染. 关键的风险因素包括重症监护室停留,广泛的抗生素和肺炎,导致高死亡率.
科学领域:
- 传染性疾病 传染性疾病
- 移植医学 移植医学
- 菌类学 菌类学是指菌类学.
背景情况:
- 固体器官移植接受者对侵入性真菌感染非常敏感.
- 在这个群体中,Candida物种是最常见的真菌病原体.
- кандидемия构成重大威胁,需要对其风险因素和结果有充分的了解.
研究的目的:
- 在成年固体器官移植接受者中确定与白血病相关的风险因素.
- 描述临床表现和涉及的常见的Candida物种.
- 确定候选血病的结果,包括死亡率,在这个脆弱的患者群体.
主要方法:
- 对2011年5月至2022年12月期间被诊断患有白血病的成年实体器官移植接受者的回顾性审查.
- 收集的数据包括患者人口统计,移植类型,候选病原体,危险因素和死亡率.
- 使用SPSS软件进行了统计分析.
主要成果:
- 在855名成年实体器官移植接受者中,26名 (3.0%) 患有白血病.
- 最常见的致病原体是Candida albicans和Candida glabrata. 这些是最常见的致病原体.
- 观察到高30天死亡率 (53.8%),与ICU护理,全方位肠道营养,宽谱抗生素和肺炎显著相关.
结论:
- 对于成年实体器官移植受体患有候选血症的人来说,仔细监测和管理至关重要.
- 应特别注意全方位肠道营养,中央导管使用,广泛的抗生素给药和侵入性手术.
- 积极的战略对于减轻与候选血症相关的高死亡率至关重要.
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