血栓糖生物合成和糖尿病的未来事件:ASCEND试验
Giovanna Petrucci1, Georgina A Buck2, Bianca Rocca1
1Section of Pharmacology, Catholic University School of Medicine, Largo F. Vito 1, Rome 00168, Italy.
European heart journal
|February 22, 2024
概括
尿液11-脱-TXB2 (U-TXM) 的升高,这是血小板激活的标志物,与糖尿病患者未来的血管事件有关. 这一发现支持了血栓素A2在糖尿病动脉瘤瘤的作用.
科学领域:
- 心血管研究研究心血管研究
- 糖尿病是一种糖尿病.
- 血栓形成和血液静止.
背景情况:
- 血红素A2 (TXA2) 在动脉血症中至关重要,其代谢物尿中的11-dehydro-TXB2 (U-TXM) 在糖尿病中升高.
- 在体内血小板激活时,U-TXM作为一种非侵入性生物标志物.
研究的目的:
- 研究U-TXM水平与糖尿病患者严重血管事件,严重出血和癌症风险之间的关联.
- 评估U-TXM作为1型或2型糖尿病患者的预测生物标志物.
主要方法:
- 在ASCEND试验测量了5948名糖尿病患者的U-TXM,然后随机分配给阿司匹林或安慰剂.
- 考克斯回归分析检查了U-TXM与结果 (严重的血管事件或再血管化,严重出血,癌症) 之间的关联,长达6.6年.
主要成果:
- 较高的U-TXM水平与年龄较大,女性性别,吸烟,2型糖尿病,更高的BMI和更高的估计膜过率有关.
- 经过调整后的分析显示,U-TXM与严重的血管事件 (HR 1.09) 和严重出血 (HR 1.16) 有边缘关联,但与癌症 (HR 1.06) 没有关联.
结论:
- 尿路11-dehydro-TXB2与糖尿病患者的严重血管事件独立相关.
- 这些发现强化了血小板TXA2在糖尿病动脉瘤病变的作用.
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