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关于COVID-19流行病的不同视角:COVID-19测试和保护性非药物干预的有效性 (第二部分)
1From the Rafik Hariri University Hospital, Beirut, Lebanon.
概括
这次审查质疑COVID-19流行病限制的科学依据. 它强调了有关诊断测试门和非药物干预措施 (如面罩) 的有效性方面的担忧.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生政策 公共卫生政策
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 被确定为COVID-19的原因,使用下一代测序.
- 实时聚合酶连锁反应 (PCR) 试验用于在患者血样本中检测冠状病毒.
研究的目的:
- 批判性地评估支持COVID-19诊断方法和非药物干预的科学证据.
- 呈现对大流行病应对措施的替代视角,重点关注疾病诊断和预防措施.
主要方法:
- 对SARS-CoV-2的基因组测序数据的分析.
- 实时聚合酶连锁反应 (PCR) 测试协议和周期值 (Ct) 值的审查.
- 检查关于口罩的有效性和普遍封锁的影响的科学文献.
主要成果:
- 在PCR测试中,高循环值 (Ct > 34) 可能表明残留遗传物质,而不是活跃的感染,具有最小的风险.
- 有限的科学证据支持病毒载量和疾病严重程度之间的相关性.
- 研究表明,面罩在预防传播或作为源控制方面对一般人群的有效性很小.
结论:
- 限制性公共卫生措施的科学有效性,包括锁定和口罩授权,由于可疑的诊断标准和有效性的证据有限,因此受到质疑.
- 这项研究引起了人们对数学建模和死亡率计算对政策决策的影响的担忧.
- 呼吁谨慎避免在未来的疫情中实施类似的限制性策略,因为它们会产生显著的负面影响.
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