用于眼部药物输送的hesperidin载入in situ凝的配方:一项全面的研究
Sefa Gözcü1, Heybet Kerem Polat2, Yakup Gültekin3
1Department of Pharmacognosy Faculty of Pharmacy, Erzincan Binali Yıldırım University, Erzincan, Turkey.
Journal of the science of food and agriculture
|February 22, 2024
概括
这项研究开发了hesperidin的in situ凝配方,用于治疗过敏结膜炎. 这种新型配方增强了hesperidin的作用.
科学领域:
- 制药科学 制药科学
- 眼科医生 眼科 眼科
- 自然产品化学 自然产品化学
背景情况:
- 过敏结膜炎是一种普遍的眼部疾病,需要有效的治疗.
- 素是一种来自Citrus sinensis的天然化合物,具有抗炎性质,但具有不良的溶解性.
- 开发先进的药物输送系统对于提高hesperidin在眼部应用中的治疗疗效至关重要.
研究的目的:
- 制定和表征一种in situ凝系统,用于将hesperidin输送到眼睛表面.
- 为了评估hesperidin加载的局部凝的抗炎潜力和眼睛安全性.
- 评估使用循环德克斯特林复合物的可行性,以提高赫斯佩里丁的可溶性和生物可用性.
主要方法:
- 使用基乙纤维素和波洛克萨默407.7制备一个in situ凝.
- 凝的特性,包括粘度,pH值,凝温度和凝时间.
- 在体外的药物释放研究,脂氧酶 (LOX) 抑制测定,细胞活力测试,以及体内Draize眼部刺激测试.
主要成果:
- 优化的hesperidin in situ凝 (BRN9-CD) 呈现出适合眼部应用的物理化学特性.
- 该配方在体外显示出显著的hesperidin释放和强大的LOX抑制.
- BRN9-CD增强了细胞活力,在Draize测试中没有显示眼部刺激,表明安全性良好.
结论:
- 含有hesperidin的in situ凝配方提供了更好的应用方便性和在眼睛表面停留时间的延长.
- 该配方经过证明的LOX抑制活性和良好的安全概况使其成为制药开发的有希望的候选者.
- 这项研究强调了in situ凝在眼科中增强难溶性抗炎药物的递送和有效性的潜力.
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