宫内暴露于SARS-CoV-2感染和新生儿早期大脑发育
Nickie Andescavage1,2,3, Yuan-Chiao Lu1, Yao Wu1
1Developing Brain Institute, Children's National Hospital, 111 Michigan Ave. NW, Washington, DC 20010, United States.
Cerebral cortex (New York, N.Y. : 1991)
|February 22, 2024
概括
怀孕期间的母体COVID-19感染可能会改变婴儿的大脑发育,导致灰质体积增加和额叶深度加快. 流行病相关的压力因素也可能影响早期神经发育.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 流行病学 流行病学
背景情况:
- 产前病毒暴露与神经发育的改变有关.
- 母亲COVID-19对婴儿大脑发育的长期影响在很大程度上是未知的.
- 随着COVID-19大流行,孕产妇出现了新的孕产妇压力因素.
研究的目的:
- 调查孕期母亲COVID-19感染对婴儿早期大脑发育的影响.
- 为了比较COVID-19暴露和不暴露的母亲出生的婴儿的大脑形态测量.
- 评估流行病相关压力因素对神经发育的影响.
主要方法:
- 华盛顿特区的婴儿前性观察队列研究 (2020年6月至2021年11月).
- 婴儿与母体COVID-19暴露 (n=47) 和未暴露的母亲 (n=55) 与大流行前对照 (n=108) 的比较.
- 主要结局包括皮质形态测量 (体积,化指数,深).
主要成果:
- 患有COVID-19的母亲的婴儿显示皮质灰质体积增加 (182.45±4.81对比167.29±2.92).
- 在COVID-19阳性母亲的婴儿 (5.01 ± 0.19对比4.40 ± 0.13) 中观察到加速的额叶深度.
- 在COVID-19未暴露母亲的婴儿中也注意到了差异,这表明了更广泛的流行病影响.
结论:
- 怀孕期间母亲的COVID-19感染与婴儿大脑结构的特定变化有关.
- 直接的病毒暴露和间接的流行病相关压力因素都可能影响早期的神经发育.
- 进一步的后续行动是有必要的,以了解这些发现的长期影响.
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