婴儿和幼儿时期骨质卡尔的参考限值:一个纵向出生队列研究
Sara S Berggren1,2, Jovanna Dahlgren1,3, Ola Andersson4
1Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Clinical endocrinology
|February 22, 2024
概括
儿童的血清骨质卡尔辛水平从出生到五岁时呈现出明显的波形模式. 这些水平受到性别,母乳养和妊娠年龄的影响,有助于临床解释.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生物化学 生物化学
- 增长和发展 增长和发展
背景情况:
- 儿童早期血清骨质卡尔辛的长度变化尚未得到充分证实.
- 骨素是骨形成的关键激素,但其在婴儿和幼儿时期的动态变化需要阐明.
研究的目的:
- 确定出生至5岁的血清骨质卡尔辛总量年龄和性别特定的参考限值.
- 调查母乳养和妊娠年龄对早期儿童血清骨质卡尔辛水平的影响.
主要方法:
- 分析了来自551名瑞典儿童的血清样本,分别是出生时,4,12,36岁和60岁的孩子.
- 使用IDS-iSYS N-MID骨质素测定方法测量血清总骨质素.
- 收集孕产妇,出生,人体测量和饮食数据.
主要成果:
- 在五个时间点确定血清骨质卡尔的性别和年龄特定的参考限值.
- 观察到类似波浪的模式:出生时低,在第一年达到顶峰,下降,并在五岁时再次上升.
- 发现较低的妊娠年龄与较高的出生骨质卡尔相关,持续的母乳养与较高的水平相关.
结论:
- 血清骨质卡尔在整个幼儿时期表现出一种特有的波形模式.
- 了解这种模式及其与性别,母乳养和妊娠年龄的关联对于临床解释至关重要.
- 这些发现为未来研究骨质卡尔在儿科骨健康中的作用提供了基础.
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