相关实验视频

Updated: Jul 2, 2025

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

血友病患者的体力活动和VIII因子水平:现实世界前性观察性研究

Fabian Tomschi¹, Jamil Hmida¹, Steffen Herzig¹

¹Department of Sports Medicine, University of Wuppertal, Wuppertal, Germany.

Haemophilia : the official journal of the World Federation of Hemophilia

|February 22, 2024

概括

患有血友病 (PwH) 的患者可以从事体力活动 (PA),但因子VIII (FVIII) 水平有所变化. 这项研究观察了PA期间的FVIII水平,在高风险活动和最小出血事件中发现更高水平.

科学领域:

血液学血液学血液学
运动医学运动医学
物理疗法物理治疗

背景情况:

定期体力活动 (PA) 对血友病 (PwH) 患者至关重要.
保持足够的因子水平对于防止PwH的PA引起的出血至关重要.
需要在普华永道的不同类型的PA所需的因子水平的具体数据.

研究的目的:

收集血友病患者 (PwH) 开始体育活动 (PA) 时的第八因子 (FVIII) 水平的真实数据.

主要方法:

一个前性的,为期12个月的观察性研究,涉及23个普华永道.
参与者通过药理学应用程序记录了PA会话和活动前的FVIII水平.
根据碰撞和伤害潜力,PA被分为低 (I类),中等 (II类) 和高 (III类) 的风险.

主要成果:

分析了来自1011个PA会话的数据 (795个Cat I,193个Cat II,23个Cat III).
平均FVIII水平在各类别之间有显著差异:第一类 (29.8%),第二类 (38.3%) 和第三类 (86.6%).
只有14%的PA开始时FVIII水平≤3%,并且发生了三个PA诱导的出血事件.

结论:

这项研究为普华永道在PA期间的FVIII水平提供了现实世界的见解.
普华永道主要参与低风险活动,中高风险类别的FVIII水平较高.
尽管一些PAs始于低FVIII水平,但出血事件并不频繁.

关键词:

年度出血率年度出血率关节病关节病是一种关节病.血友病 (Hemophilia) 是一种血友病.药物动力学药物动力学罕见病是一种罕见的疾病.运动运动运动运动运动.

更多相关视频

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

Published on: September 30, 2021

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes

Published on: June 3, 2014

相关概念视频

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

Extrinsic and Intrinsic Pathways of Hemostasis

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...