怀孕预防对布鲁塞拉流产的影响 美国野牛 (Bison bison) 的流产
Pauline Nol1,2, Rebecca Frey3, Morgan Wehtje1,4
1United States Department of Agriculture, Animal and Plant Health Inspection Service, Veterinary Services, Center for Epidemiology and Animal Health, 2150 Centre Avenue, Building B, Fort Collins, Colorado 80526, USA.
Journal of wildlife diseases
|February 22, 2024
概括
使用免疫避孕预防对布鲁塞拉流产病毒阳性的野牛怀孕显著减少了女性B.流产流产事件. 然而,对整体群体血病传播的影响需要进一步调查.
科学领域:
- 野生动物疾病生态学 野生动物疾病生态学
- 兽医免疫学 兽医免疫学
- 保护生物学 保护生物学
背景情况:
- 在野牛 (Bison bison) 中,Brucella abortus的传播主要通过分娩产物发生.
- 了解和减轻疾病的传播对于管理野生动物群体中的牛病至关重要.
研究的目的:
- 评估免疫避孕药在减少怀孕野牛中布鲁塞拉流产的有效性.
- 评估预防怀孕对野牛群内横向疾病传播的影响.
主要方法:
- 一个复制的实验涉及黄石国家公园的布鲁塞拉病毒阳性和病毒阴性野牛.
- 治疗组接受了一种释放性腺激素的基于激素的免疫避孕药,而对照组没有接受治疗.
- 多年来监测B. abortus流产事件 (与分娩相关) 和哨戒动物的血清转化.
主要成果:
- 免疫避孕在一个复制品 (治疗复制品1) 中导致零分泌事件,而在对照组 (控制复制品1) 中为12例.
- 第二次复制显示治疗组 (2事件) 与对照组 (5事件) 的脱落减少.
- 在治疗组中没有任何哨戒动物进行血清转换,这表明防止了水平传播,而其他组的哨戒动物则进行了血清转换.
结论:
- 避孕治疗成功地阻止了B. abortus在单个阳性雌性野牛身上流产.
- 避孕药治疗在降低群体内总体血病患病率方面的有效性需要进一步研究.
相关概念视频
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
01:21Intrauterine Drug Delivery Systems
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...