瑞典运动神经元疾病的发病率增加:在2002-2021年期间进行的一项基于人口的研究
Sofia Imrell1, Fang Fang2, Caroline Ingre3,4
1Department of Neurology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden. sofia.imrell@regionorebrolan.se.
Journal of neurology
|February 22, 2024
概括
在瑞典,运动神经元疾病 (MND) 的发病率已上升至每10万人/年超过4例. 在过去20年中观察到的这种增加,需要进一步调查潜在的原因.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 运动神经元疾病 (MND),主要是肌缩侧面硬化症,很少见,原因不明.
- 之前的报道表明,在20世纪后期,西方国家中MND发病率上升.
- 本研究更新了瑞典2002-2021年期间的MND发病率数据.
研究的目的:
- 为瑞典提供关于运动神经元疾病 (MND) 发病率的最新数据.
- 分析过去20年来MND发病率的趋势.
- 通过年龄,性别和地区来检查发病率的变化.
主要方法:
- 使用了瑞典国家患者登记册 (2002-2021) 的数据.
- 每10万人/年计算的发病率.
- 分析了与人口人口统计学相关的数据,包括年龄,性别和地区.
主要成果:
- 原始发病率从2000年代初的每10万人/年3.5-3.7增加到2008年以后的4.0-4.6.
- 男性的发病率更高,70-84岁年龄组的发病率达到顶峰.
- 瑞典北部的发病率可能更高,但不具有统计学意义.
结论:
- 瑞典的MND发病率现在超过每10万人/年4例.
- 这一比例高于其他欧洲国家和之前的瑞典研究.
- 需要进一步的研究来确定这种上升是否反映了真正的发病率上升或改进的注册表数据.
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