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Koichiro Kaneko¹, Michinobu Nagao², Kaori Ueda²

¹Department of Diagnostic Imaging & Nuclear Medicine, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. kaneko.koichiro@twmu.ac.jp.

Annals of nuclear medicine

|February 22, 2024

概括

全身数字11C-氨酸 (MET) PET/CT成像有助于检测胸部癌症患者的局部复发 (LR). 瘤与正常的比率 (TNR) 比SUVmax更好,用于区分LR与辐射亡 (RN).

科学领域:

核医学是一种核医学.
在瘤学瘤学.
放射学放射学是一门学科.

背景情况:

对大脑转移的立体射线外科手术 (SRS) 可以导致局部复发 (LR) 或放射性亡 (RN).
准确区分LR和RN对于患者管理至关重要.
全身成像为全面评估提供了潜力.

研究的目的:

评估全身数字11C-氨酸 (MET) PET/CT,用于评估胸部癌症患者,在SRS后怀疑LR.
为了比较瘤与正常比率 (TNR) 和最大标准化吸收值 (SUVmax) 在区分LR与RN的有效性.
调查全身扫描在检测额外头骨复发中的实用性.

主要方法:

45名肺癌或乳腺癌患者在SRS后怀疑LR经过大脑和全身MET-PET/CT扫描.
瘤与正常比率 (TNR) 和SUVmax在LR和RN组之间进行了比较.
进行了接收器操作特征 (ROC) 分析,以确定诊断准确性.
分析了脑外复发,脑内复发,主要部位和初始治疗之间的关联.

主要成果:

在区分LR和RN时,TNR显示曲线下面积 (0.82) 比SUVmax (0.79) 更大,比SUVmax (0.79).
最佳的TNR切割值 (2.12) 比传统的PET系统高.
全身扫描检测到31.1%的患者出现了额外头骨复发.
接受非手术治疗的晚期或小细胞肺癌患者的复发率 (68.8%) 与手术治疗患者 (10.3%) 相比显著更高.

结论:

使用TNR的数字MET-PET/CT成像是区分LR和RN的有价值的工具,与传统PET相比,它的切割值更高.
全身扫描有效地检测到额外的复发,特别是在接受非手术治疗的晚期胸部癌症患者.

关键词:

11C-甲氨酸的使用方法大脑转移的转移.数字PET/CT可以使用.额外骨复发的发生.立体无线电外科手术立体无线电外科手术整个身体扫描扫描.

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