癌症中的托芬代谢和金氨酸代谢产物:系统营养和代谢影响
Alessio Molfino1, Giovanni Imbimbo, Carmen Gallicchio
1Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Current opinion in clinical nutrition and metabolic care
|February 22, 2024
概括
托 (Trp) 代谢和Kynurenine (Kyn) 代谢产物显著影响与癌症相关的营养不良和缓冲症. 了解这些途径为改善癌症患者营养提供了新的治疗目标.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 代谢研究研究 代谢研究
背景情况:
- 托 (Trp) 代谢在癌症中至关重要,超过95%的代谢都指向Kynurenine (Kyn) 途径.
- 基因代谢物影响免疫反应和神经传递,影响癌症患者的营养不良和缓解症.
- 免疫功能障碍和代谢变化在癌症和营养不良中很常见.
研究的目的:
- 阐明 (Trp) 代谢和 (Kyn) 代谢产物在与癌症相关的营养和代谢变化中的作用.
- 在癌症的背景下,探索Trp代谢对免疫和能量平衡的影响.
- 研究Trp和Kyn调节对癌症患者相关的中枢神经系统机制的影响.
主要方法:
- 在癌症中对 (Trp) 代谢和Kynurenine (Kyn) 途径的当前文献的综述.
- 对动物研究的分析,研究了胺-2,3-二氧化酶 (IDO) 抑制的作用.
- 检查将Kynurenines与肌肉代谢和炎症联系起来的生化机制.
主要成果:
- 基因代谢物调节淋巴细胞活动,并与癌症和营养不良期间的免疫功能障碍有关.
- 在动物模型中,抑制氨酸-2,3-二氧化酶 (IDO) 显示了部分抗炎作用,但没有保持肌肉质量.
- kynurenines可能通过NAD+生物合成和反应性氧物种 (ROS) 生成促进肌肉代谢.
- 通过血清素生物合成的托芬代谢会影响癌症的食欲控制,而Kynurenines与疲劳有关.
结论:
- Trp代谢和Kynurenines与癌症中的免疫和能量平衡有关.
- 调节Trp和Kynurenines会影响食欲,疲劳和肌肉消耗 (缓解症).
- 对这些途径的进一步研究可以导致针对癌症相关营养问题的新型治疗策略.
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