异常静态和动态局部功能连接在第一次发作精神分裂症:一个休息状态fMRI研究
概括
动态区域相同步 (DRePS) 显示了第一发精神分裂症 (FES) 患者的变化的静态局部功能连接 (FC). 结合静态和动态FC指标可以提高精神分裂症的诊断准确性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 精神分裂症涉及全球功能连接 (FC) 障碍.
- 在未经治疗的第一发精神分裂症 (FES) 中,局部FC动态尚不清楚.
- 动态区域相同步 (DRePS) 为本地FC分析提供了一种新的方法.
研究的目的:
- 在FES患者中全面检查静态和动态局部FC变化.
- 将DRePS衍生的静态局部FC与传统的区域同质性 (ReHo) 方法进行比较.
- 探索当地FC指标与FES中的临床/认知特征之间的关联.
主要方法:
- 休息状态fMRI用于FES患者 (N=74) 和健康对照 (HCs,N=41).
- 动态区域相同步 (DRePS) 用于本地FC分析.
- 静态局部FC指标与肯德尔对应系数 (KCC-ReHo) 和频率一致性 (Cohe-ReHo) 进行了比较.
主要成果:
- 与HC患者相比,FES患者在特定的大脑区域 (例如,回,海马体,基底) 呈现出静态局部FC的增加.
- 在FES和HC之间没有发现动态局部FC指标的显著差异.
- 静态和动态FC特征的组合显著预测了全球功能评估和简短视觉空间记忆测试修订分数.
- 包括DRePS的零交叉比提高了对精神分裂症检测的分类准确性.
结论:
- 精神分裂症与变化的静态局部功能连接性有关.
- 动态局部FC指标本身并没有区分FES和HC.
- 当与静态测量相结合时,DRePS,特别是其动态指标,显示出作为精神分裂症诊断生物标志物的潜力.
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