在泰国青年中开展艾滋病毒暴露前预防试点项目
Supattra Rungmaitree1, Peerawong Werarak2, Wadchara Pumpradit3
1Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
PloS one
|February 22, 2024
概括
每日口服预暴露预防 (PrEP) 对于泰国青少年的艾滋病毒预防是可行的,但遵守仍然是一个挑战. 需要新的策略来改善PrEP在这个人群中的吸收和有效性.
科学领域:
- 青少年健康 青少年健康
- 预防艾滋病毒 预防艾滋病毒
- 药理学 药理学是指药理学的学科.
背景情况:
- 在向青少年提供抗逆转录病毒暴露前预防 (PrEP) 方面存在知识和经验差距.
- 青少年是艾滋病毒预防工作的关键人口.
研究的目的:
- 评估高风险泰国青少年每日口服天诺福维尔/emtricitabine (TDF-FTC) 暴露前预防 (PrEP) 的可行性,安全性和遵守性.
- 评估PrEP对性传播感染 (STIs) 和风险补偿行为的影响.
主要方法:
- 一项试点研究招募了61名艾滋病毒阴性泰国青少年 (14-20岁) 报告风险行为.
- 参与者每天接受TDF-FTC治疗24周,并定期进行HIV,STI,脏和骨密度测试.
- 通过细胞内特诺福维尔二酸盐 (TFV-DP) 水平来测量粘附性.
主要成果:
- 80.3%的患者在第24周保持药量;36%和29%的患者在第12周和第24周保持药量 (≥6片/周).
- 与较低的坚持相关的因素包括年轻男性与男性发生性关系 (MSM),基线性传播感染和减少避孕套使用.
- 没有观察到脏或骨毒性;HIV血清转化为零. 传播性疾病的患病率从31%降至18%.
结论:
- 每天口服的TDF-FTC PrEP在高风险的泰国青少年中是可行的,可以接受的,并且耐受良好.
- 较低的坚持是一个重大挑战,需要针对青少年的具体策略,如长效PrEP选项,以有效预防艾滋病毒.
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