等待和观察:埃塞俄比亚阿姆哈拉地区的气管瘤监测策略,埃塞俄比亚
Eshetu Sata1, Fikre Seife2, Zebene Ayele1
1Trachoma Control Program, The Carter Center, Addis Ababa, Ethiopia.
PLoS neglected tropical diseases
|February 22, 2024
概括
在埃塞俄比亚,监测了可预防失明的主要原因 - - 气管瘤的复发. 一种"等待和观察"的方法显示,TF的患病率低于5%,避免了不必要的大量药物管理.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 消除后的瘤复发是控制计划的全球关注点.
- 监测调查经常显示临界高患病率 (≥5%的瘤性炎症-毛囊[TF]),导致昂贵的大规模药物管理 (MDA).
- 从统计学变化中区分真正的复发是具有挑战性的,特别是当TF的流行率接近5%时.
研究的目的:
- 为了监测埃塞俄比亚阿姆哈拉地区的气管瘤复发情况,使用
- 等待和观察"的方法.
- 评估与传统TF流行调查相结合的替代指标的有效性.
- 为了确定MDA干预措施是否在FT流行率接近5%门的地区是合理的.
主要方法:
- 在Metema和Woreta城区进行了多阶段的集群调查.
- 经过认证的分级人员评估了1至9岁儿童的气管瘤症状 (TF).
- 采集了干燥的血斑和结膜拭子,用于感染和血清学 (Pgp3) 分析.
主要成果:
- 监测后的TF患病率在Metema为3.6%,在Woreta Town为2.5%,两者均低于5%的门.
- 克拉米迪亚形虫感染的发病率很低 (1.2%在Woreta镇,0%在Metema).
- 血清转化率表明,这两个地区的传播水平都很低.
结论:
- 这两个地区的TF流行率低于5%,Chlamydia trachomatis感染和传播最小.
- 大规模药物管理 (MDA) 的干预被认为是不必要的,支持"等待和观察"战略.
- 这种监测方法可能会减少MDA活动,从而节省成本并减少抗生素的使用.
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