使用LAMS进行EUS引导排水后的新发糖尿病:试点研究
Teodora Man1, Alice Spulber Sfara2, Lidia Neamti3
1Department of Gastroenterology, Regional Institute of Gastroenterology and Hepatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. . dance.teodora@gmail.com.
Journal of gastrointestinal and liver diseases : JGLD
|February 22, 2024
概括
在27%的患者中,用内镜排水治疗隔墙性亡 (WON) 导致新发糖尿病 (NOD). 广泛的亡和多次手术增加了NOD风险,突出了严重胰腺炎的严重并发症.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 胰腺疾病 胰腺疾病
背景情况:
- 围墙性亡 (WON) 是一种严重的胰腺炎并发症.
- 死亡性胰腺炎增加患糖尿病 (DM) 的风险.
研究的目的:
- 在有症状的WON患者中评估新发型糖尿病 (NOD) 的频率,使用光线对立金属支架 (LAMS) 进行内镜后超声波 (EUS) 引导排水.
主要方法:
- 对从有症状的WON患者获得的前性收集数据的回顾性分析,这些患者接受了EUS引导的LAMS排水治疗.
- 与无症状WON和健康对照对一年DM发生的比较.
- 根据美国糖尿病协会标准定义的糖尿病.
主要成果:
- 27%的非糖尿病有症状的WON患者在切除支架后一年内发生NOD.
- 与对照组相比,有症状的WON患者的NOD发生率更高 (18.9%与2%相比).
- 高龄,广泛的亡 (>50%),以及身体尾部的WON位置与NOD有关. 直接内镜性瘤切除术 (DEN) 是一个显著的风险因素 (OR=7.05).
结论:
- 用EUS引导排水治疗的症状性WON与27%的新发糖尿病 (NOD) 发生率有关.
- 广泛的胰腺亡和更多的直接内镜亡术 (DEN) 疗程是NOD发展的重要危险因素.
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