克服在瘤学中发现和实施公平的药物基因组测试的障碍
Sharon P Shriver1, Devon Adams1, Brittany Avin McKelvey2
1ACS CAN, Washington, DC.
概括
药物基因组学 (PGx) 研究偏向于欧洲人口,可能会加剧癌症护理差异. 确保公平的PGx应用对于所有患者的个性化瘤治疗至关重要.
科学领域:
- 药物基因组学和精密医学在瘤学.
- 基因组变异及其对药物反应的影响.
- 基因研究和应用中的健康公平.
背景情况:
- 药物基因组学 (PGx) 对于个性化癌症治疗至关重要,优化药物的有效性和安全性.
- 遗传祖先影响药物反应,但PGx研究往往忽视了这一点,可能造成差异.
- 目前的PGx理解和临床使用不成比例地集中在欧洲血统的人身上.
研究的目的:
- 检查药物基因组学 (PGx) 研究和瘤学应用对欧洲祖先群体的偏见.
- 讨论这种偏见对PGx发现,获得护理和临床实施的影响.
- 倡导公平的PGx发现和应用在所有人群的癌症护理中.
主要方法:
- 审查目前对PGx在瘤学中的科学理解.
- 分析与遗传祖先相关的PGx研究和发现中的潜在偏见.
- 讨论对PGx的临床实施,获取和理解的影响.
主要成果:
- 与其他群体相比,欧洲血统的个人在PGx知识和临床整合方面更先进.
- 这种偏见可能导致癌症治疗结果和不良药物事件的差异.
- 尽管有可行的发现和证明的好处,但PGx在常规瘤护理中的整合仍然有限.
结论:
- 在瘤学中,目前的药物基因组学 (PGx) 状态在不同的遗传祖先群体中并不公平.
- 解决PGx研究,发现和应用中的偏见对于实现癌症护理中的健康公平至关重要.
- 建议建议克服障碍,促进有效,公平的PGx在瘤学中的实施.
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