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相关实验视频

Updated: Jul 2, 2025

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
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白物质可塑性支持多域自适应计算机化认知训练后的认知收益.

Xiangwei Dai1,2, Sihan Liu3, Yumeng Li2

  • 1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.

The journals of gerontology. Series A, Biological sciences and medical sciences
|February 22, 2024
PubMed
概括

计算机认知训练 (CCT) 在老年人中改善了认知功能和白质神经可塑性. 这种基于家庭的干预有效地抵消了认知衰退,显示了持久的好处.

关键词:
认知老龄化 认知老龄化计算机化认知训练是计算机化的认知训练.执行职能 执行职能 执行职能神经可塑性 神经可塑性白色的物质是白色的物质.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 认知心理学 认知心理学

背景情况:

  • 认知能力下降是老年人群的一个重大问题.
  • 白质 (WM) 完整性和神经可塑性对于认知功能至关重要.
  • 计算机化认知训练 (CCT) 是一个潜在的干预措施,以减轻与年龄相关的认知变化.

研究的目的:

  • 评估基于家庭的,多领域的,适应性的CCT程序的有效性.
  • 研究CCT对白质 (WM) 神经可塑性的影响.
  • 评估接受CCT的老年人神经心理表现的变化.

主要方法:

  • 128名居住在社区的老年人被随机分为CCT或对照组.
  • 干预组参与了为期一年的家庭适应性CCT (30分钟,每周2次).
  • 在干预前和后进行了神经心理测试和扩散/T1加权MRI.

主要成果:

  • 在CCT组的Stroop Color-Word Test (SCWT) 显著改善,而对照组的下降.
  • 在CCT组中,左后丘脑辐射的轴向扩散率增加,与SCWT反应时间缩短相关.
  • 在不同组之间没有观察到灰色物质体积的显著变化.

结论:

  • 多域适应性CCT是有效和可行的,以抵消老年人的认知衰退.
  • WM的神经可塑性,特别是轴向扩散性的变化,是CCT认知益处的基础.
  • 这项研究阐明了支持CCT对衰老认知的积极影响的神经机制.