外周炎症生物标志物作为超CKemia风险评估后预测工具
Wenhao Xu1, Zhong Dong1, Yu Wang1
1Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230000, China; Anhui Public Health Clinical Center, Hefei 230000, China.
概括
像中性粒细胞与淋巴细胞比率 (NLR) 这样的炎症生物标志物可以帮助在发作后早期检测出超CKemia. 这有助于预防狂宫痛解并改善患者的护理.
科学领域:
- 生物化学 生物化学
- 临床诊断 临床诊断 临床诊断
- 炎症研究 炎症研究
背景情况:
- 发作后的CK高血压会带来拉布地质溶解的风险.
- 早期发现CK高血症对于及时干预至关重要.
- 需要可访问的生物标志物,以便及时诊断.
研究的目的:
- 评估炎症生物标志物,特别是中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与淋巴细胞的比率 (PLR),用于发作后早期检测CKCK高血症.
- 确定在患者中NLR和PLR的诊断潜力.
- 为了解决高CK血和其并发症的诊断延迟.
主要方法:
- 从2022年10月到2023年10月的回顾性数据分析.
- 单变量分析 (P < 0.05) 接下来是斯皮尔曼等级相关性和二进制逻辑回归.
- 接收器运行特征 (ROC) 曲线用于确定与有关的CK高血症的切断值.
主要成果:
- 在98名发作患者中,有31.63%患有CK高血症.
- 在高CK血和正常CK组之间白细胞,中性粒细胞,CRP和NLR的显著差异 (P <0.05).
- 白细胞,NLR和CRP与高CKH相关;确定了最佳切断点.
结论:
- 血白细胞,CRP和NLR的升高是后CK高血风险的重要指标.
- 这些生物标志物可以加强管理中的临床决策.
- 研究结果支持使用这些标记物来改进患者护理策略.
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