功能神经系统疾病中的皮质醇:状态,特征和预后生物标志物
Samantha Weber1, Janine Bühler2, Fabian Messmer2
1Department of Neurology, Psychosomatic Medicine Unit, Inselspital Bern University Hospital, University of Bern, 3012 Bern, Switzerland; University of Zurich, Psychiatric University Hospital Zurich, Department of Psychiatry, Psychotherapy and Psychosomatics, 8032 Zurich, Switzerland.
Journal of psychosomatic research
|February 22, 2024
概括
平的皮质醇唤醒反应 (CAR) 可能是功能神经障碍 (FND) 的特征标记. 较早的CAR峰值和更高的皮质醇振幅 (CAmp) 显示了FND患者临床结果的预后价值.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
背景情况:
- 功能神经障碍 (FND) 与生物压力失调有关.
- 在FND患者中观察到平坦的皮质醇唤醒反应 (CAR).
- 作为FND中的状态或特征生物标志物,CAR变化的作用需要进一步研究.
研究的目的:
- 纵向评估FND患者皮质醇唤醒反应 (CAR) 的变化.
- 为了确定FND中的CAR变化是否作为状态或特征生物标志物.
- 评估皮质醇水平对FND临床结果的预后价值.
主要方法:
- 唾液皮质醇测量在53名FND患者在两个时间点 (M0和M8),八个月间隔.
- 计算了皮质醇唤醒反应 (CAR) 和皮质醇振幅 (CAmp).
- 用功能运动障碍评分表 (S-FMDRS) 和临床全球印象 (CGI) 评分来评估临床结果.
主要成果:
- 不管临床结果如何,平坦的CAR水平在M0和M8之间保持一致.
- 在M0之前的CAR峰值与M8的良好临床结果相关 (p=0.013).
- 在M0时更高的皮质醇振幅 (CAmp) 预测了M8时更好的临床结果 (p=0.03).
结论:
- 一个平的CAR可以作为FND的特征标志物.
- 较早的CAR峰值可以作为FND的状态生物标志物.
- 皮质醇幅度 (CAmp) 显示出作为FND的预后生物标志物的预测潜力,需要进一步研究.
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