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Updated: Jul 2, 2025

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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瘤获得的体质突变会影响形状,从而消除ABCG2介导的耐药性

Tomoka Gose1, Ali Rasouli2, Sepehr Dehghani-Ghahnaviyeh2

  • 1Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
|February 22, 2024
PubMed
概括

在ABCG2输送器 (Q393K) 中的瘤突变通过将其锁定在非功能状态中来防止药物耐药性. 这一发现为传送机制和药物相互作用提供了洞察力.

关键词:
在ABC运输器上,ABC运输器这就是ABCG2ABCG2.癌症 癌症 癌症 癌症规范性变化 规范性变化 规范性变化遗传变异是一种基因变异.

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