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Updated: Jul 2, 2025

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什么影响了降解剂-抗体结合剂 (DAC) 的活性?

Yaolin Guo1, Xiaoxue Li2, Yang Xie3

  • 1Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, 610212, Sichuan, China.

European journal of medicinal chemistry
|February 22, 2024
PubMed
概括

降解剂-抗体结合物 (DACs) 通过将抗体向与PROTACs相结合,增强向蛋白质降解 (TPD). DACs提高了选择性,并克服了潜在的癌症治疗的 PROTAC 局限性.

关键词:
抗体与药物的结合物.降解剂 - 抗体合物这就是 PROTACs.

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