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产前暴露在per-和多基物质和儿童行为问题

Jeong Weon Choi¹, Jiwon Oh², Deborah H Bennett²

¹Department of Environmental Science, Baylor University, Waco, TX, USA.

Environmental research

|February 22, 2024

概括

产前暴露于per-和多基物质 (PFAS) 与儿童行为问题的增加有关. 特定的PFAS,如PFNA,与儿童的外部化和侵略性行为有关.

科学领域:

环境健康环境健康
发育儿科发育儿科
毒理学毒理学毒理学

背景情况:

产前暴露在per-和多基基物质 (PFAS) 中可能会影响儿童的发育,但现有的研究表明存在矛盾.
这项研究调查了产前PFAS暴露与儿童行为问题之间的关联.

研究的目的:

检查特定PFAS产前暴露与儿童行为结果之间的关系.
评估PFAS混合物对儿童行为的影响.

主要方法:

这项研究包括来自MARBLES队列的177对母婴对,他们有自闭症谱系障碍 (ASD) 的家族风险.
在母体血清中测量了9个PFAS,跨越了三个月;儿童行为在3岁时使用儿童行为检查表 (CBCL) 进行了评估.
统计分析包括负二项回归和加权定量总回归,以评估单个PFAS,混合物和行为得分之间的关联.

主要成果:

更高的产前 perfluorononanoate (PFNA) 暴露与增加的外部化问题和侵略性行为有关.
提高PFNA, perfluorooctane sulfonate (PFOS) 和 perfluorodecanoate (PFDA) 的水平与睡眠问题得分更高相关.
在被诊断为ASD或其他神经发育问题儿童中,PFAS和行为问题之间的关联更为明显,在典型发育儿童中没有显著发现.

结论:

产前接触某些PFAS与3岁儿童行为问题的风险增加有关.
研究结果表明,包括PFNA,PFOS和PFDA在内的特定PFAS可能会导致行为问题,特别是在脆弱人群中.
结果应谨慎解释,因为该研究的重点是对具有更高ASD家族可能性的队列.

关键词:

行为问题行为问题和多醇基物质是多和多的.产前暴露在产前暴露.

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