微塑料和TiO2纳米颗粒混合物作为对两动物的新兴威胁:对公胚胎的案例研究
Raquel Fernanda Salla1, Fagner Neves Oliveira2, Jaqueline C Jacintho3
1Laboratory of Environmental Biotechnology and Ecotoxicology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil; Post-graduation Program of Biotechnology and Environmental Monitoring, Federal University of São Carlos (UFSCar), Campus Sorocaba, Sorocaba, São Paulo, Brazil.
Environmental pollution (Barking, Essex : 1987)
|February 22, 2024
概括
这项研究表明,二氧化纳米颗粒 (TiO2 NPs) 损害了公胚胎的生存和化. 微塑料的影响较少,可能是由于与NP的聚合,但在化胚胎中引起腹.
科学领域:
- 环境毒理学环境毒理学
- 两动物生态毒理学
- 发展生物学 发展生物学
背景情况:
- 两动物种群面临着全球性的下降,新出现的污染物如微塑料和纳米颗粒等也与此有关.
- 关于两动物胚胎发育过程中微塑料和纳米颗粒对生态有毒性的数据有限.
- 了解这些影响对于两动物保护工作至关重要.
研究的目的:
- 评估聚乙烯微塑料 (PE MPs) 和二氧化纳米颗粒 (TiO2 NPs) 对牛胚胎 (Aquarana catesbeiana) 的发育毒性.
- 调查PE MPs和TiO2 NP的单独和组合暴露的影响.
- 评估对生存,化,心率和形态测量的潜在影响,使用适应的青胚胎发育试验 (FETAX).
主要方法:
- 牛青胚胎被暴露在EP MPs (60 mg/L) 和TiO2 NPs (10 μg/L) 的环境相关度中,单独和组合.
- 青胚胎发育试验 (FETAX) 协议被调整为96小时的暴露期.
- 分析了生存率,化率,心率,形态测量数据和腹.
主要成果:
- TiO2 NPs显著降低了生存率和化率,可能是因为它们干扰了化酶.
- 与单独的TiO2NP相比,联合暴露 (Mix组) 的毒性降低,这可能是由于聚合物限制了NP的可用性.
- PE MPs附着在胆管上,提供保护,但在化胚胎中引起腹,表明透调节受损.
结论:
- 这项研究提供了微塑料和纳米粒子混合物对两动物发育毒性的第一个证据.
- TiO2 NPs对两动物胚胎发育构成重大风险,而PE MPs对两动物胚胎发育构成较小但显著的风险.
- 费塔克斯协议是评估环境污染物的两胚胎毒性的宝贵工具.
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