烟草吸烟和静脉血栓塞栓症之间没有遗传因果关系:一个双样本的门德尔随机化研究
Hong-Cheng Du1, Yun-Fei Zheng1, Meng-Qi Shen1
1Graduate School of Guangxi University of Chinese Medicine, Nanning, China.
Thrombosis and haemostasis
|February 22, 2024
概括
这项门德尔随机化研究没有发现任何遗传证据表明,目前或过去的烟草吸烟会导致静脉血栓栓塞 (VTE),深静脉血栓塞 (DVT) 或肺栓塞 (PE). 这些发现挑战了之前的观察性研究,这些研究表明存在联系.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 关于烟草吸烟与静脉血栓塞栓症 (VTE) 风险之间的关联正在进行的辩论.
- 观察性研究已经表明了相关性,但因果关系仍在争论中.
- 遗传关联研究对于阐明因果关系至关重要.
研究的目的:
- 使用孟德尔随机化 (MR) 研究目前和过去的烟草吸烟对静脉瘤风险的因果关系.
- 为了区分与吸烟相关的VTE风险中的遗传倾向与环境因素.
- 提供遗传证据来解决现有文献中相互矛盾的发现.
主要方法:
- 进行了两样单变量和多变量门德尔随机化分析.
- 利用来自欧洲人口的大型全基因组关联研究的总结级数据.
- 为了确保结果的可靠性,使用了包括MR-Egger回归和MR-PRESSO在内的强有力的灵敏度分析.
主要成果:
- 统一的MR分析显示,目前或过去的吸烟对静脉瘤,深静脉血栓症 (DVT) 或肺栓塞 (PE) 没有显著的因果关系.
- 多变量MR分析产生了一致的结果,加强了缺乏显著的因果关系的说法.
- 在灵敏度分析中没有发现异质性或质性证据.
结论:
- 这项研究提供了强有力的遗传证据,即无论是现在还是过去的烟草吸烟都不会对VTE,DVT或PE的风险产生因果影响.
- 这些发现与之前的一些观察性研究相矛盾,表明这些分析中存在潜在的混因素.
- 这些结果支持得出的结论是,从遗传角度来看,吸烟不会影响VTE风险.
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