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母亲接触聚乙烯纳米塑料会通过扰乱代谢概况,导致后代小鼠视网膜发育和功能缺陷

Shiyi Xiong¹, Jincan He², Hao Qiu³

¹Shanghai Key Laboratory of Maternal Fetal Medicine, Department of Fetal Medicine and Prenatal Diagnosis Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 201204, China.

|February 22, 2024

概括

母亲暴露在聚烯纳米塑料 (PS-NP) 中会损害新生小鼠视网膜的发育和功能. 这项研究显示PS-NP沉积在视网膜组织中,损害细胞数量,血管化和视觉反应,突出显示视觉系统的潜在风险.

科学领域:

环境毒理学环境毒理学
神经科学是一个神经科学.
眼科医生眼科眼科

背景情况:

微塑料和纳米塑料 (MP/NP) 是普遍存在的环境污染物.
人体中的积累引发了健康问题.
对于MP/NP对视网膜发育和功能的影响仍然在很大程度上未知.

研究的目的:

研究聚乙烯纳米塑料 (PS-NP) 对视网膜发育和功能的影响和分子机制.
使用小鼠模型来评估母亲PS-NP暴露的影响.

主要方法:

在怀孕和哺乳期间,母亲暴露于100nmPS-NP (10 mg/L).
评估视网膜组织学,细胞计数 (脉状细胞和双极细胞),血管发育和电网膜图 (ERG) 响应.
代谢和转录分析以确定分子变化.
监管网络分析以确定关键途径.

主要成果:

在新生小鼠视网膜组织中的PS-NP沉积.
视网膜结节和双极细胞数量的减少.
视网膜血管发育受损和异常ERG反应.
增加氧化应激和关键氨基酸的失调 (例如,谷氨酸,氨酸,氨酸).
在血管生成和视觉系统发育途径中的失调基因的丰富.
Fos基因介导的途径被确定为潜在的目标.

结论:

母亲接触PS-NP会对新生小鼠视网膜发育和视觉功能产生不利影响.
PS-NPs诱导细胞和分子变化,包括氧化应激和代谢失调.
这些发现为纳米塑料的视觉毒性提供了关键的见解.

关键词:

在这里,Fos Fos Fos Fos Fos Fos.聚乙烯纳米塑料的聚乙烯纳米塑料.视网膜发育视网膜发育视网膜功能视网膜功能毒素基因组学毒素基因组学视觉毒性视觉毒性

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Teratogenicity

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