草药在心血管疾病中提供对铁过载的调节:为未来的应用提供信息
Jia Liu1, Liangyan Deng1, Liping Qu1
1State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China.
Journal of ethnopharmacology
|February 22, 2024
概括
铁过载通过促进铁亡,影响心血管疾病 (CVD). 草药,特别是黄类药物,通过调节关键细胞通路,在结合铁和保护心血管疾病方面表现有前途.
科学领域:
- 心血管研究研究心血管研究
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 铁对心肌细胞至关重要,但过载或缺乏铁会显著影响心血管疾病 (CVD).
- 铁过载有助于多克索鲁比 (DOX) 心肌病变,动脉样硬化和心肌缺血-再输损伤 (MI/RI) 通过脂质过氧化物生产.
- 铁过载诱导的细胞死亡是ferroptosis的潜在机制,这是一种特定形式的调节细胞死亡.
研究的目的:
- 概述心肌细胞中的铁代谢和铁.
- 审查草药和提取物用于预防心血管疾病中铁过载.
主要方法:
- 在主要的科学数据库 (ScienceDirect,PubMed,Google Scholar,Web of Science) 进行系统的文献搜索.
- 包括来自中国数据库 (CNKI,WanFang),经典书籍和临床报告的数据.
- 分析收集的关于铁代谢,铁和心血管疾病中草药干预的信息.
主要成果:
- 各种草药,包括中国的草药处方 (例如,Salvia miltiorrhiza注射,Gegen Qinlian) 和提取物 (黄类,类,多类) 显示出治疗潜力.
- 黄素因其强大的铁化性质而受到重视.
- 草药调节Nrf2,AMPK和KAT5/GPX4信号通路,以减少心血管疾病中的铁过载和脂质过氧化.
结论:
- 草药通过调节铁过载和铁症来提供心血管保护.
- 这些天然化合物可以作为开发策略的有希望的模板,以防止心血管疾病中铁过载.
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