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七种人类基因组胺H3受体异型体的药理学表征

Meichun Gao1, Mabel E Dekker1, Rob Leurs1

  • 1Department of Medicinal Chemistry, Amsterdam Institute of Molecular Life Sciences, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, the Netherlands.

European journal of pharmacology
|February 22, 2024
PubMed
概括

这项研究揭示了组胺H3受体 (H3R) 拼接变体之间的独特药理学特征. 较短的H3R异构体对激动剂和逆激动剂表现出改变的结合亲缘关系,影响神经系统疾病的药物发现.

关键词:
具有约束性的选择性构成性活动 构成性活动有效性 有效性.在GPCR中,GPCR是指GPCR.基因组胺 H(3) 受体受体异构体的异构体形式

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