在COVID-19住院治疗3年后的长期放射和肺功能异常:一个纵向队列研究
Xiaoyu Han1,2,3, Lu Chen4,3, Liyan Guo5,3
1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
The European respiratory journal
|February 22, 2024
概括
大多数COVID-19幸存者在3年内表现出改善的肺功能和减少异常. 然而,超过三分之一的人仍然患有持续的肺部问题,影响了他们的呼吸系统健康和扩散能力.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 评估COVID-19后的长期肺部后果对于患者管理至关重要.
- 肺部残留异常和肺功能受损可能会在感染后持续存在.
研究的目的:
- 纵向评估COVID-19后长达3年的残留肺异常和肺功能.
- 为了比较COVID-19幸存者和非COVID-19对照组之间的结果.
主要方法:
- 一个前性的,对COVID-19幸存者的纵向队列研究,初始肺部异常.
- 随访包括肺功能测试,6分钟步行距离 (6MWD),CT扫描和症状问卷在出院后的6个月,1年,2年和3年.
- 追溯招募非COVID-19对照组进行比较.
主要成果:
- 在COVID-19幸存者中,从6个月到3年观察到肺部对一氧化碳 (DLCO),6MWD和肺部异常的扩散能力的逐渐改善.
- 在3年后,持续的异常与呼吸道症状,下6MWD和异常DLCO相关.
- 在3年后,COVID-19幸存者与对照人群相比,DLCO损伤和呼吸道症状的发生率明显更高.
结论:
- 虽然大多数COVID-19患者在肺部成像和功能方面出现了恢复,但很大一部分患者出现了持续的异常.
- 在COVID-19后3年持续的肺部异常与持续的呼吸系统症状和肺部扩散能力的降低有关.
- 长期监测对于COVID-19幸存者残留肺部变化至关重要.
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