药物使用和肺结核风险之间的关联在支气管切除症患者中:台湾的一项基于人口的回顾性队列研究
Kuang-Ming Liao1,2, Chung-Shu Lee3,4, Yu-Cih Wu5
1Department of Internal Medicine, Chi Mei Medical Center Chiali Branch, Tainan, Taiwan.
BMJ open respiratory research
|February 22, 2024
概括
静止剂治疗显著降低了支气管切除症患者的结核病风险,显示出剂量依赖的保护作用. 这表明他类药物可以通过控制呼吸道炎症来帮助预防结核病.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性呼吸道疾病增加结核病 (TB) 的风险.
- 关于支气管切除症患者结核病风险的数据有限.
- 类药物具有抗炎性质.
研究的目的:
- 调查他类药物治疗是否能降低支气管切除症患者的结核病风险.
- 探索他类药物对结核病发病率的剂量依赖作用.
主要方法:
- 使用全国数据库进行回顾性队列研究.
- 包括支气管切除症患者,分析他类药物的使用 (DDD,持续时间).
- 使用考克斯回归与时间依赖的共变量来评估结核病发病率.
主要成果:
- 在调整后,静止剂使用者患结核病的风险降低了41% (HR0.59,P=0.0087).
- 使用高剂量他类药物 (>180 DDD/年) 显示出更强的保护作用 (HR 0.32,P=0.0255).
- 静止剂治疗表明剂量依赖的保护性关联与降低结核病风险.
结论:
- 静止剂治疗与支气管切除症患者的结核病风险降低有关.
- 观察到他类药物对结核病的剂量依赖的保护作用.
- 在这种人群中,他类药物可以通过调节呼吸道炎症来减轻结核病风险.
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