相关实验视频

Updated: Jul 2, 2025

Development of an In Vitro Ocular Platform to Test Contact Lenses

Development of an In Vitro Ocular Platform to Test Contact Lenses

Published on: April 6, 2016

改进的三氨酸乙化物释放型隐形眼镜,基于循环凝和高水静压辅助复合

Carolina Marto-Costa¹, Nadia Toffoletto¹, Madalena Salema-Oom²

¹Centro de Química Estrutural (CQE) - Institute of Molecular Sciences and Chemical Engineering Department, Instituto Superior Técnico - University of Lisbon, Av. Rovisco Pais, 1049-001 Lisboa, Portugal; Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, Campus Universitário, Quinta da Granja, 2829-511 Monte da Caparica, Almada, Portugal.

Carbohydrate polymers

|February 22, 2024

概括

使用2-propyl-β-cyclodextrin (HP-β-CD) 载有三氨乙胺 (TA) 的隐形眼镜显示药物递送得到改善. 高水静压灭菌可增强TA负载和持续释放,用于治疗眼部炎症.

科学领域:

眼科药物输送眼科药物输送
生物材料科学生物材料科学
聚合物化学聚合物化学

背景情况:

隐形眼镜提供了长时间的眼睛药物接触,但像皮质类固醇这样的脂性药物具有挑战性,可以有效地加载和释放.
改善液凝隐形眼镜的药物加载和释放对于开发先进的眼疗法至关重要.

研究的目的:

通过使用2-基烯-β-环德 (HP-β-CD) 来研究增强triamcinolone acetonide (TA) 载荷和释放的方法.
评估HP-β-CD结合和高水位压力 (HHP) 灭菌对水凝特性和TA输送对眼部应用的影响.

主要方法:

使用了两种方法:在聚合之前 (HEMA/i-CD) 和处理后 (HEMA/p-CD) 结合HP-β-CD.
评估了水凝的特性 (含水量,透性,粗性,透射性,刚性).
药物加载,释放动力学,细胞毒性和ex vivo眼组织透性被评估. 应用了HHP绝育方法.

主要成果:

HEMA/i-CD水凝对TA有较高的亲和力,可以在一天内持续释放.
高酸灭菌显著增加了TA负载能力超过60%通过循环德素-TA复合体的形成.
释放的TA透到眼组织,并表现出抗炎作用. 安全性通过细胞毒性和易怒性测试得到证实.

结论:

含有HP-β-CD的水凝隐形眼镜对持续的眼部输送三氨酸有效.
该系统为眼内注射提供了一个有前途的替代方案,用于治疗眼睛后部疾病,HHP杀菌可增强药物负载.

关键词:

循环德克斯特林 (Cyclodextrin) 是一种循环德克斯特林.糖尿病性黄斑胀糖尿病性黄斑胀药物排放的隐形眼镜可以释放药物高水静压杀菌的高压杀菌方法三亚氨基诺乙化物.

更多相关视频

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

相关概念视频

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...