美国人口的基于肌素的其他GFR估计 - 类似的表现,相同的差距 - 是时候继续前进了吗?
1Division of Internal Medicine, University of the Witwatersrand Faculty of Health Sciences-Wits Donald Gordon Medical Centre, School of Clinical Medicine, Johannesburg, South Africa; Medical Research Council/Wits University Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Kidney international
|February 22, 2024
概括
欧洲功能联盟 (EKFC) 的方程显示,美国人群的表现有所改善. 特定于人群的EKFC方程在估计功能方面显示出最高的准确性,优于其他模型.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床化学 临床化学
背景情况:
- 精确估计膜过率 (GFR) 对于诊断和管理病至关重要.
- 现有的GFR估计方程,例如2021年慢性病流行病学协作 (CKD-EPI) 方程,在不同种群中存在局限性.
- 欧洲功能联盟 (EKFC) 的方程提供了替代方法,包括特定人群和无种族配方.
研究的目的:
- 评估欧洲功能联盟 (EKFC) 方程在美国队列中的表现.
- 在EKFC框架内比较人口特异性 (EKFCPS) 和无种族 (EKFCRF) Q值的准确性.
- 评估EKFC方程与CKD-EPI 2021方程之间的偏差和精度.
主要方法:
- 对美国队列的分析,以评估GFR估计.
- 将EKFCPS和EKFCRF方程与CKD-EPI 2021方程进行比较.
- 偏差的评估和估计GFR (eGFR) 在测量GFR的30%以内的百分比.
主要成果:
- 与CKD-EPI 2021方程相比,EKFCPS和EKFCRF方程表现出较少的偏差.
- 在测量GFR的30%以内的EGFR的百分比在CKD-EPI 2021 (79.2%) 和EKFCRF (80.1%) 之间是可比的.
- EKFCPS方程显示性能有所改善,81.1%的eGFR值在测量GFR的30%之内.
结论:
- EKFC方程是估计美国人口的GFR的一个有价值的工具.
- 种群特异性EKFC方程 (EKFCPS) 在这个队列中为GFR估计提供了更高的准确性.
- 这些发现支持EKFC方程在美国患者的临床实践中的更广泛的实用性和潜在采用.
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