与双特异性T细胞吸引剂治疗相关的心血管毒性
Ahmed Sayed1, Malak Munir1, Sanam M Ghazi2
1Ain Shams University Faculty of Medicine, Cairo, Egypt.
Journal for immunotherapy of cancer
|February 22, 2024
概括
心血管不良事件 (CVAE) 是对双特异性T细胞参与剂 (BTE),一种新型癌症疗法的重大关注. 这项研究发现,大约五分之一的BTE报告涉及CVAE,这带来了更高的死亡风险.
科学领域:
- 在瘤学瘤学.
- 药物监督 药物监督 药物监督
- 血液学 血液学 血液学
背景情况:
- 双特异性T细胞参与剂 (BTE) 代表了血液恶性瘤的新型治疗类.
- 之前的研究缺乏足够的规模来充分评估与BTE相关的心血管不良事件 (CVAE).
研究的目的:
- 系统地评估与BTE相关的CVAE的频率和特征,使用营销后监测数据.
- 识别特定的BTE和相关的CVAE,报告率不成比例高.
主要方法:
- 利用美国食品和药物管理局的不良事件报告系统 (FAERS) 来获取2014-2023年的数据.
- 计算调整报告赔率比率 (aRORs),以比较CVAE比率与背景水平.
- 评估的死亡率和风险比率 (RRs) 确定不良事件.
主要成果:
- 在3668个与BTE相关的案件中,747个 (20.4%) 涉及CVAEs.
- 作为一个类别,BTE显示出致命CVAE的风险更高 (aROR 1.29).
- 德克利斯塔马布与心肌炎和休克风险增加有关; 布利纳图莫马布与散布的血管内凝血和低血压有关.
- 与非CVAE相比,CVAE的死亡率更高 (31.1%对17.4%).
结论:
- 这项营销后监测研究强调,CVAE报告约有20%的双特异性T细胞参与病例.
- 与BTE相关的心血管不良事件具有显著的死亡风险,需要密切监测.
更多相关视频
09:34Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
3.3K
06:08Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
1.3K
相关概念视频
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Tumor Immunotherapy
524
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
524
Heart Failure Drugs: Inotropic Agents
588
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
588
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
