鼻炎与突发性类风湿性疾病之间的关联:基于人口的研究.
Vanessa L Kronzer1, John M Davis2, Andrew C Hanson3
1Mayo Clinic, Rochester, Minnesota, USA kronzer.vanessa@mayo.edu.
RMD open
|February 22, 2024
概括
先发性鼻炎显著增加患各种类风湿性疾病的风险,包括抗脂综合征和Sjögren病. 这表明鼻炎可能在这些疾病的发展中发挥作用.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 类风湿性疾病包括一组自身免疫和炎症性疾病,影响关节,肌肉和结缔组织.
- 许多类风湿性疾病的病因尚不完全理解,正在调查潜在的环境触发因素.
- 鼻炎是一种鼻炎,是一种常见的疾病,具有潜在的全身影响.
研究的目的:
- 调查鼻炎病史与随后各种类风湿性疾病的发展之间的关联.
- 为了确定鼻炎是否是潜在的风险因素或预测发生性类风湿性疾病的预测因素.
主要方法:
- 采用基于人口的病例控制研究设计,包括在1995年至2014年期间被诊断患有类风湿性疾病的个人.
- 根据年龄,性别和电子健康记录历史记录的持续时间,对每个病例进行了三组对照.
- 使用诊断代码识别了鼻炎,并使用后勤回归模型计算了风湿病发病率的几率比率 (ORs),调整了混因子.
主要成果:
- 这项研究确定了1729例突发性风湿病例和5187例对照病例.
- 先前发生的鼻炎与抗脂综合征 (OR 7.0),Sjögren病 (OR 2.4),血管炎 (OR 1.4),多发性肌痛 (OR 1.4) 的风险增加有关.
- 急性鼻炎与血清阴性类风湿性关节炎 (OR1.8) 的风险增加有关,并且在疾病发病前5-10年和从未吸烟者中,这种关联最强.
结论:
- 鼻炎的病史与几种类风湿性疾病的发病率增加有关.
- 这些发现表明,鼻炎可能有助于类风湿性疾病的发病.
- 进一步的研究是有必要的,以探索将鼻炎和类风湿性疾病发展联系在一起的生物机制.
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