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与新生儿脊髓切割相关的表观遗传过程.

Nicholas J Collins1, Taylor S Campbell1, Aimee L Bozeman2

  • 1Department of Psychological and Brain Sciences, University of Delaware, Newark, Delaware, USA.

Developmental psychobiology
|February 22, 2024
PubMed
概括

脊髓损伤 (SCI) 在发育过程中改变了来自大脑的神经营养因子 (BDNF) 基因甲基化和表达. 在BDNF基因的表观遗传变化可以作为SCI结果和治疗有效性的生物标志物.

关键词:
在 Bdnf 找发展发展发展发展发展.表观遗传学是指表观遗传学.这是一种神经营养素 (neurotrophin).塑性的可塑性 塑性脊髓损伤导致的脊髓损伤

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科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

  • 脊髓损伤 (SCI) 影响脊髓可塑性,部分由脑衍生神经营养因子 (BDNF) 介导.
  • 在减轻SCI后果方面,BDNF的输送显示出希望.
  • 之前的研究已经确定了SCI之后BDNF基因的表观遗传变化.

研究的目的:

  • 研究SCI后早期发育期间BDNF基因的局部特异性表观遗传修饰和表达模式.
  • 确定BDNF基因表观遗传活性是否可以作为SCI病因和治疗干预的生物标志物.

主要方法:

  • 新生小鼠 (P1) 受到了胸部脊髓损伤.
  • 在P7,P14和P21收集了宫和腰椎脊髓组织.
  • 量化了BDNF表达,局部特异性甲基化 (EXON IX和IV) 和全球甲基化水平.

主要成果:

  • SCI诱导BDNF表达的局部特异性减少,与损伤尾部甲基化增加相关.
  • 在P14时间点观察到BDNF表达升高.
  • 全球甲基化水平也被评估跨时间点.

结论:

  • 在发育性SCI之后,BDNF基因的表观遗传调节发生了改变.
  • BDNF基因甲基化模式可以作为了解SCI进展的生物标志物.
  • 这些表观遗传标记可以告知脊髓损伤干预措施的有效性.